Causes Of Type 2 Diabetes

Causes Of Type 2 Diabetes

If a Type 2 diabetes arises, different causes or triggers come together. So far known factors are heredity, obesity and lack of exercise, insensitivity to insulin, impaired insulin secretion and impaired production of certain gut hormones.

Hereditary Predisposition

As with type 1 diabetes a genetic predisposition must be present in type 2 diabetes. But without triggering factors like overweight and sedentary lifestyle, this genetic trait would not come to light. Both are caused by an unhealthy lifestyle. Type 2 diabetes occur in children and adolescents.

Insulin Resistance

Obesity and lack of exercise cause a type 2 diabetes, which isis due to another problem in the body: the insulin resistance. Insulin resistance means that the hormone insulin cannot work properly. It is still formed by the body’s own beta cells, but cannot develop full effect due to “errors” of the cells. So sufficient quantity of sugar cannot passes from blood into the cells. The consequence is that the sugar remains in the blood and so the blood sugar concentration is increases.

The Role Of GLP-1

In type 2 diabetes, the body’s own intestinal hormones such as GLP-1 (glucagon-like peptide-1), are not formed in sufficient quantity. These hormones normally ensure that the body responded adequately to the intake of carbohydrates, for example, by the insulin secretion is stimulated. In type 2 diabetics, due to lack of GLP-1, this process can no longer function properly.

Decrease In Insulin Production

Also the production of insulin plays important  role in the emergence of type 2 diabetes. The  beta cells of the pancreas are still able to produce insulin; while at the beginning even they produce an excess amount of insulin to overcome the described insulin resistance. Over time however, insulin production is declines. The consequence is that the sugar remains in the blood and so the blood sugar concentration is raised.