Type 3 Diabetes

Type 3 Diabetes

The term type 3 diabetes summarizes various forms of Diabetes Mellitus, which can not be clearly assigned to the “classical” foam  of Type 1 Diabetes or Type 2 Diabetes. Type 3 is usually based on a destruction of pancreatic tissue by other diseases and a resulting lack of Insulin Hormone. However, it can also have a variety of other causes. type 3 diabetes occur very rarely.

Causes And Types Of  Type 3 Diabetes

Causes of  type 3 diabetes are following:

  • Injury to the pancreas (Pankreopriver Diabetes)
  • Genetic changes
  • Hormonal causes
  • Viral infections

Injury to the Pancrease (Pankreopriver Diabetes)

Type 3  diabetes mellitus is most often  so-called Pancreoprivic Diabetes. Pankreoprivic means that  due to damage of pancreas can no longer produce adequately amount of insulin. However, before the hormone function (endocrine function) is impaired, sufferers have usually been complaints with digestion because in this diseased production of digestive enzymes (exocrine function) from  pancreas decreases first.

Inflammation Of The Pancreas

A chronic inflammation of the pancreas (chronic pancreatitis) may lead to massive tissue damage, causing the diabetes type 3. By far the most common cause of chronic pancreatitis is alcohol consumption.

Surgical Removal Of The Pancreas

The surgical removal of pancreatic tissue in a tumor can triggered type 3 diabetes because  by the loss of pancreatic tissues production of insulin is decreased. it can also lead to a removal of the glucagon producing cells of the pancreas. Thus glycemic control is also disturbed. Glucagon is secreted at low blood glucose to raise the blood sugar level again. If this is not possible, it can lead to a life-threatening blood sugar level (hypoglycemia).

Diabetes Type 3 In Metabolic Diseases

The metabolic disorder cystic fibrosis (Cystic Fibrosis) is accompanied by a viscosity of body secretions. The digestive enzymes produced in the pancreas are especially thick and “stick”. The accumulation of exudates can also lead to chronic inflammation of the pancreas, as a result production of insulin is affected and a type 3 of diabetes can develop.

In another metabolic disorder, Hemochromatosis,  absorption of iron through the intestines is increases. This leads to iron overload in many organs of the body. In the pancreas, excessive iron deposition leads to tissue damage, causing a type 3 diabetes.  Sufferers often have a very brown skin pigmentation, which is why you will also find a so-called “bronze diabetes” speaks in a combination with a diabetes type 3.

Genetic Causes

Different genetic causes can lead to a type 3 diabetes. In this case, both the production of insulin as well as the effect of insulin is to be affected.

Genetic Diseases With Inadequate Insulin Production

This group includes the forms of diabetes MODY and LADA. It involves rare forms of diabetes that are often misdiagnosed initially as type 1 diabetes and type 2 diabetes. They fall mostly on the fact that the symptoms of the respective disease are uncommon. Even with trisomy 21, a Type 3 diabetes occur.

For information about MODY click here.

For information about LADA click here.

Genetic Disorders With Failures Of Insulin Action

These diabetes-type-3-forms include, the insulin resistance Type A syndrome and Lipatrophischer Diabetes (Lawrence syndrome). It is very rare genetic defects in which the body tissue has a very pronounced insulin resistance and greatly increased in blood glucose levels occur. Insulin resistance means that the insulin cannot work properly on its target cells.

For information click Type A syndrome.

For information click Lipatrophischer Diabetes (Lawrence syndrome).

Diabetes Type 3 – Hormonal Causes

A Type 3 diabetes may also occur under other hormone disorders in which the regulation system of the body is disrupted. These include, for example, Cushing’s Syndrome and Acromegaly.

For information about Cushing’s Syndrome click here.

For information click Acromegaly.

Diabetes Type 3 By Viral Infections

In rare cases, certain viral infections can cause a type 3 diabetes.  unborn childrens are at maximum risk, the virus can be transmitted from mother in to children. In viral infection mainly the pancreas is attacked.

Congenital Rubella Infection

As a congenital (congenital) rubella infection refers to a transmission of rubella virus from the mother to the fetus during pregnancy. If an infection occurs after the first trimester, it may cause malfunctions of individual organs, the rubella virus can cause inflammation of the pancreas (pancreatic) and thus a lack of insulin produced and the resulting diabetes type 3 leads to increased blood sugar levels.

Cytomegalovirus Viral Infection

The cytomegalovirus (CMV, human herpesvirus 5) belongs to the group of herpes viruses and is very widespread worldwide. The CMV can lead to inflammation of the pancreas (pancreatitis). The inflammation of the pancreas can lead to a lack of insulin.

Coxsackie Virus Infection

Infection with Coxsackie virus causes the formation of antibodies against the virus. Since the Coxsackie virus has great structural similarities with beta cells which produced  insulin, the antibodies may also the attack beta cells of the pancreas and result in diabetes type 3  with insulin deficiency.

 

 

 

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